Structure of PDB 5izl Chain B Binding Site BS01

Receptor Information
>5izl Chain B (length=498) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AGRRVNVNVGVLGHIDSGKTALARALSTTASRGITLDLGFSCFSVPLPAR
LRSSLPGEPLLQVTLVDCPGHASLIRTIIGGAQIIDLMMLVIDVTKGMQT
QSAECLVIGQIACQKLVVVLNKIDLLPEGKRQAAIDKMTKKMQKTLENTK
FRGAPIIPVAAKPGGPETEAPQGIPELIELLTSQISIPTRDPSGPFLMSV
DHCFSIKGQGTVMTGTILSGSISLGDSVEIPALKVVKKVKSMQMFHMPIT
SAMQGDRLGICVTQFDPKLLERGLVCAPESLHTVHAALISVEKIPYFRGP
LQTKAKFHITVGHETVMGRLMFFSPAPDNFDQEPILDSFNFSQEYLFQEQ
YLSKGHCPRQQWALVEFEKPVTCPRLCLVIGSRLDADIHTNTCRLAFHGI
LLHGLEDRNYADSFLPRLKVYKLKHKRAMDDYSVINIQLFVGLKVHLSTG
ELGIIDSGKFKIHIPGGLSPESKKILHVVLSLTFKRYVFDTHKRMVQS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5izl Chain B Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5izl Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation.
Resolution2.72 Å
Binding residue
(original residue number in PDB)		T21 T48
Binding residue
(residue number reindexed from 1)		T20 T35
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D17 K20 T21 T48 H96
Catalytic site (residue number reindexed from 1) D16 K19 T20 T35 H71
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0035368 selenocysteine insertion sequence binding
GO:0043021 ribonucleoprotein complex binding
Biological Process
GO:0001514 selenocysteine incorporation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5izl, PDBe:5izl, PDBj:5izl
PDBsum5izl
PubMed27708257
UniProtP57772|SELB_HUMAN Selenocysteine-specific elongation factor (Gene Name=EEFSEC)

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