Structure of PDB 5iz8 Chain B Binding Site BS01

Receptor Information
>5iz8 Chain B (length=322) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHHHHHMLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPA
VCVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRR
YAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLR
NLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHC
TENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATN
EDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALW
DMSMLKNLIHSKHKMIAMGSAA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5iz8 Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Resolution3.06 Å
Binding residue
(original residue number in PDB)		H427 G487 L488
Binding residue
(residue number reindexed from 1)		H28 G88 L89
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5iz8, PDBe:5iz8, PDBj:5iz8
PDBsum5iz8
PubMed28759015
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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