Structure of PDB 5iu9 Chain B Binding Site BS01

Receptor Information

>5iu9 Chain B (length=422) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

FNLKYTVEEELRAGTKIANVTADAKVAGFALGNRQPYLRVISNSEPRWVN
LSPAGLLITKQKIDRDAVCRQTPKCFISLEVMSNSMEICVIKIEIIDVND
NAPRFPTNHIDIEISENAAPGTRFPLEGASDPDSGSNGIQTYTITPNDIF
GLEIKTRGDGSKIAELVVEKTLDRETQSRYTFELTAEDGGDPPKSGTVQL
NIKVIDSNDNNPVFDEPVYTVNVLENSPINTLVIDLNATDPDEGTNGEVV
YSFINFVSNLTKQMFKIDPKTGVITVNGVLDHEELHIHEIDVQAKDLGPN
SIPAHCKVIVNVIDINDNAPEIKLLSENSEMVEVSENAPLGYVIALVRVS
DNDSGANGKVQCRLQGNVPFRLNEFESFSTLLVDGRLDREQRDMYNLTIL
AEDSGYPPLRSSKSFAVKVTDL

Ligand information

Ligand ID

InChI

InChI=1S/Ca/q+2

InChIKey

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Name

CALCIUM ION

PDB chain

5iu9 Chain B Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5iu9 Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy.
Resolution	3.59 Å
Binding residue (original residue number in PDB)	E10 E11 D65 D67 D101
Binding residue (residue number reindexed from 1)	E9 E10 D64 D66 D100
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5iu9, PDBe:5iu9, PDBj:5iu9
PDBsum	5iu9
PubMed	27787195
UniProt	F8W3X3\|PCD19_DANRE Protocadherin-19 (Gene Name=pcdh19)

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