Structure of PDB 5inp Chain B Binding Site BS01

Receptor Information

>5inp Chain B (length=248) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAYLK
KRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNLLCVN
VSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDSTTVIFAGD
TNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAAYK
HRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTLNVVL

Ligand information

>5inp Chain C (length=9) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ccgaattcg

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	5inp Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Resolution	1.947 Å
Binding residue (original residue number in PDB)	H236 S239 D272 N274 R276 W307 I317 Y321 H359
Binding residue (residue number reindexed from 1)	H114 S117 D150 N152 R154 W185 I195 Y199 H237

Enzymatic activity

Enzyme Commision number

3.1.4.-

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity

View graph for
Molecular Function

External links

PDB	RCSB:5inp, PDBe:5inp, PDBj:5inp
PDBsum	5inp
PubMed	27060144
UniProt	Q9JJX7\|TYDP2_MOUSE Tyrosyl-DNA phosphodiesterase 2 (Gene Name=Tdp2)

[Back to BioLiP]