Structure of PDB 5ic4 Chain B Binding Site BS01

Receptor Information
>5ic4 Chain B (length=92) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMH
ILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFY
Ligand information
Receptor-Ligand Complex Structure
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PDB5ic4 Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		Y204 S205 W206 R207 S249 F250
Binding residue
(residue number reindexed from 1)		Y20 S21 W22 R23 S65 F66
Enzymatic activity
Enzyme Commision number 3.4.22.56: caspase-3.
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5ic4, PDBe:5ic4, PDBj:5ic4
PDBsum5ic4
PubMed27367566
UniProtP42574|CASP3_HUMAN Caspase-3 (Gene Name=CASP3)

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