Structure of PDB 5hx5 Chain B Binding Site BS01

Receptor Information
>5hx5 Chain B (length=168) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NPMEAMDPHIFYFHFKNSWLCFTMEVVKHHSPVSWKRGVFRNRHAERCFL
SWFADDILSPNTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIKTAR
LYYFDDTDYQEGLRSLSQEGASVEIMGYKDFKYCWENFVYNDDEPFKPWD
GLDYNFLDLDSKLQEILE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5hx5 Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5hx5 1.92 Angstrom Zinc-Free APOBEC3F Catalytic Domain Crystal Structure.
Resolution2.33 Å
Binding residue
(original residue number in PDB)		H249 C280 C283
Binding residue
(residue number reindexed from 1)		H44 C75 C78
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.4.38: single-stranded DNA cytosine deaminase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:5hx5, PDBe:5hx5, PDBj:5hx5
PDBsum5hx5
PubMed27139641
UniProtQ8IUX4|ABC3F_HUMAN DNA dC->dU-editing enzyme APOBEC-3F (Gene Name=APOBEC3F)

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