Structure of PDB 5hmp Chain B Binding Site BS01

Receptor Information
>5hmp Chain B (length=712) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ELYTQYNRVWIPDPEEVWKSAEIAKDYRVGDKVLRLLLEDGTELDYSVNP
ESLPPLRNPDILVGENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGII
LVAMNPYKQLPIYGDAIIHAYSGQNMGDMDPHIFAVAEEAYKQMARNNRN
QSIIVSGESGAGKTVSARYAMRYFATVSKHVEDKVLASNPITEAVGNAKT
TRNDNSSRFGKYTEISFDEQNQIIGANMSTYLLEKSRVVFQSENERNYHI
FYQLCASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVNDRAEMVETQKT
FTLLGFKEDFQMDVFKILAAILHLGNVQITAVGNERSSVSEDDSHLKVFC
ELLGLESGRVAQWLCNRKIVTSSETVVKPMTRPQAVNARDALAKKIYAHL
FDFIVERINQALQFSGKQHTFIGVLDIYGFETFDVNSFEQFCINYANEKL
QQQFNMHVFKLEQEEYMKEDIPWTLIDFYDNQPVIDLIEAKMGILELLDE
ECLLPHGTDENWLQKLYNNFVNRNPLFEKPRMSNTSFVIQHFADKVEYKC
EGFLEKNRDTVYDMLVEILRASKFHLCANFFQENRTTVGSKFRSSLYLLM
ETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSY
PSRWTYIEFYSRYGILQESDKKEVCKVVLHRLIQDSNQYQFGKTKIFFRA
GQVAYLEKLRLD
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5hmp Chain B Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5hmp The myosin X motor is optimized for movement on actin bundles.
Resolution2.397 Å
Binding residue
(original residue number in PDB)		T168 S216
Binding residue
(residue number reindexed from 1)		T164 S207
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) S163 G164 T168 N212 S215 S216 G438 E440
Catalytic site (residue number reindexed from 1) S159 G160 T164 N203 S206 S207 G429 E431
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003774 cytoskeletal motor activity
GO:0005524 ATP binding
Cellular Component
GO:0016459 myosin complex

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:5hmp, PDBe:5hmp, PDBj:5hmp
PDBsum5hmp
PubMed27580874
UniProtQ9NQX4|MYO5C_HUMAN Unconventional myosin-Vc (Gene Name=MYO5C)

[Back to BioLiP]