Structure of PDB 5hkp Chain B Binding Site BS01
Receptor Information
>5hkp Chain B (length=311) Species:
10090
(Mus musculus) [
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TGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYN
RVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNA
MDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPEL
RERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAV
ASLHPKRKQVAELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKH
GAKMNALDSLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQM
GNEAVQQILSE
Ligand information
>5hkp Chain D (length=11) Species:
9606
(Homo sapiens) [
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SPRGCADGRDA
Receptor-Ligand Complex Structure
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PDB
5hkp
Crystal structure of a tankyrase 1-telomere repeat factor 1 complex.
Resolution
2.2 Å
Binding residue
(original residue number in PDB)
R361 S363 L368 G371 Y372 L396 N401 Y405 H407 D425 W427 F429 E434 R440
Binding residue
(residue number reindexed from 1)
R38 S40 L45 G48 Y49 L73 N78 Y82 H84 D102 W104 F106 E111 R117
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:5hkp
,
PDBe:5hkp
,
PDBj:5hkp
PDBsum
5hkp
PubMed
27050267
UniProt
Q6PFX9
|TNKS1_MOUSE Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=Tnks)
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