Structure of PDB 5h25 Chain B Binding Site BS01

Receptor Information
>5h25 Chain B (length=357) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYEC
HSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIIN
PITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLV
AIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKE
SYDYPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKP
GKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQV
GKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDAS
IWRWDRL
Ligand information
>5h25 Chain D (length=29) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SMFSSNRQKILERTEILNQEWKQRRIQPV
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5h25 Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy
Resolution2.88 Å
Binding residue
(original residue number in PDB)		W103 H104 S105 K106 D109 Y154 S159 H160 P161 R201 L246 L247 L315 G316 D317 L318 M336 F372 W373 Q374 L391 E392 E394 R420
Binding residue
(residue number reindexed from 1)		W27 H28 S29 K30 D33 Y78 S83 H84 P85 R125 L170 L171 L232 G233 D234 L235 M253 F289 W290 Q291 L308 E309 E311 R337
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:5h25, PDBe:5h25, PDBj:5h25
PDBsum5h25
PubMed28092155
UniProtO75530|EED_HUMAN Polycomb protein EED (Gene Name=EED)

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