Structure of PDB 5h1k Chain B Binding Site BS01

Receptor Information

>5h1k Chain B (length=690) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GAMGIRNSMGQEPRTLPPSPNWYCARCSDAVPGGLFGFAARTSVFLVRVG
PGAGESPGTPPFRVIGELVGHTERVSGFTFSHHPGQYNLCATSSDDGTVK
IWDVETKTVVTEHALHQHTISTLHWSPRVKDLIVSGDEKGVVFCYWFNRN
DSQHLFIEPRTIFCLTCSPHHEDLVAIGYKDGIVVIIDISKKGEVIHRLR
GHDDEIHSIAWCPLPGEDCLSIGCYLATGSKDQTIRIWSCSRGRGVMILK
LPFLKERLWLTLHWPSNQPTQLVSSCFGGELLQWDLTQSWRRKYTLFSAS
SEGQNHSRIVFNLCPLQTEDDKQLLLSTSMDRDVKCWDIATLECSWTLPS
LGGFAYSLAFSSVDIGSLAIGVGDGMIRVWNTLSIKNNYDVKNFWQGVKS
KVTALCWHPTKEGCLAFGTDDGKVGLYDTYSNKPPQISSTYHKKTVYTLA
WGPPVPPMSLPSLALYSCGGEGIVLQHNPWKLSGEAFDINKLIRDTNSIK
YKLPVHTEISWKADGKIMALGNEDGSIEIFQIPNLKLICTIQQHHKLVNT
ISWHHEHGSQPELSYLMASGSNNAVIYVHNLKTVIESSPESPVTITEPYR
TLSGHTAKITSVAWSPHHDGRLVSASYDGTAQVWDALREEPLCNFRGHRG
RLLCVAWSPLDPDCIYSGADDFCVHKWLTSMQDHSRPPQG

Ligand information

>5h1k Chain D (length=12) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

caauuuuugaca

............

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5h1k Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5
Resolution	1.9 Å
Binding residue (original residue number in PDB)	N13 W14 Y15 R33 R66 R284 R335 R359 G380 F381 Y383 W422 K428 E556 K579 L580 N605 F705
Binding residue (residue number reindexed from 1)	N21 W22 Y23 R41 R74 R257 R308 R332 G353 F354 Y356 W395 K401 E523 K546 L547 N572 F672
Binding affinity	PDBbind-CN: Kd=0.24uM

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:5h1k, PDBe:5h1k, PDBj:5h1k
PDBsum	5h1k
PubMed	27881601
UniProt	Q8TEQ6\|GEMI5_HUMAN Gem-associated protein 5 (Gene Name=GEMIN5)

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