Structure of PDB 5gwz Chain B Binding Site BS01

Receptor Information
>5gwz Chain B (length=299) Species: 229032 (Porcine epidemic diarrhea virus CV777) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLRKMAQPSGVVEKCIVRVCYGNMALNGLWLGDIVMCPRHVIASSTTSTI
DYDYALSVLRLHNFSISSGNVFLGVVSATMRGALLQIKVNQNNVHTPKYT
YRTVRPGESFNILACYDGAAAGVYGVNMRSNYTIRGSFINGACGSPGYNI
NNGTVEFCYLHQLELGSGCHVGSDLDGVMYGGYEDQPTLQVEGASSLFTE
NVLAFLYAALINGSTWWLSSSRIAVDRFNEWAVHNGMTTVGNTDCFSILA
AKTGVDVQRLLASIQSLHKNFGGKQILGHTSLTDEFTTGEVVRQMYGVN
Ligand information
Receptor-Ligand Complex Structure
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PDB5gwz Michael Acceptor-Based Peptidomimetic Inhibitor of Main Protease from Porcine Epidemic Diarrhea Virus
Resolution2.444 Å
Binding residue
(original residue number in PDB)		F139 G142 C144 H162 Q163 L164 E165 P188 T189 L190
Binding residue
(residue number reindexed from 1)		F138 G141 C143 H161 Q162 L163 E164 P187 T188 L189
Enzymatic activity
Catalytic site (original residue number in PDB) H41 G142 C144
Catalytic site (residue number reindexed from 1) H40 G141 C143
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:5gwz, PDBe:5gwz, PDBj:5gwz
PDBsum5gwz
PubMed28287727
UniProtP0C6V6|R1A_PEDV7 Replicase polyprotein 1a (Gene Name=1a)

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