Structure of PDB 5gwy Chain B Binding Site BS01

Receptor Information
>5gwy Chain B (length=305) Species: 277944 (Human coronavirus NL63) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGSSGLKKMAQPSGCVERCVVRVCYGSTVLNGVWLGDTVTCPRHVIAPST
TVLIDYDHAYSTMRLHNFSVSHNGVFLGVVGVTMHGSVLRIKVSQSNVHT
PKHVFKTLKPGDSFNILACYEGIASGVFGVNLRTNFTIKGSFINGACGSP
GYNVRNDGTVEFCYLHQIELGSGAHVGSDFTGSVYGNFDDQPSLQVESAN
LMLSDNVVAFLYAALLNGCRWWLCSTRVNVDGFNEWAMANGYTSVSSVEC
YSILAAKTGVSVEQLLASIQHLHEGFGGKNILGYSSLCDEFTLAEVVKQM
YGVNL
Ligand information
Receptor-Ligand Complex Structure
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PDB5gwy Structure of Main Protease from Human Coronavirus NL63: Insights for Wide Spectrum Anti-Coronavirus Drug Design.
Resolution2.852 Å
Binding residue
(original residue number in PDB)		F139 G142 C144 H163 Q164 I165 E166 L167 G168 P189 S190 L191
Binding residue
(residue number reindexed from 1)		F142 G145 C147 H166 Q167 I168 E169 L170 G171 P192 S193 L194
Enzymatic activity
Catalytic site (original residue number in PDB) H41 G142 C144
Catalytic site (residue number reindexed from 1) H44 G145 C147
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:5gwy, PDBe:5gwy, PDBj:5gwy
PDBsum5gwy
PubMed26948040
UniProtP0C6U6|R1A_CVHNL Replicase polyprotein 1a (Gene Name=1a)

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