Structure of PDB 5g4q Chain B Binding Site BS01

Receptor Information
>5g4q Chain B (length=369) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKISVSKNDLENALRYLQAFLDKKDASSIASHIHLEVIKEKLFLKASDSD
IGLKSYIFTQSSDKEGVGTINGKKFLDIISCLKDSNIILETKDDSLAIKQ
NKSSFKLPMFDADEFPEFPVIDPKVSIEVNAPFLVDAFKKIAPVIEQELA
GILMQFDQKHQTLSVVGTDTKRLSYTQLEKISIHSTEEDISCILPKRALL
EILKLFYENFSFKSDGMLAVIENEMHTFFTKLIDGNYPDYQKILPKEYIS
SFTLGKEEFKESIKLCSSLSSTIKLTLEKNNALFESLDSEHSETAKTSVE
IEKGLDIEKAFHLGVNAKFFLEALNALGTTQFVLRCNEPSSPFLIQESLD
EKQSHLNAKISTLMMPITL
Ligand information
Ligand ID2HQ
InChIInChI=1S/C8H4ClNO2/c9-4-1-2-6-5(3-4)7(11)8(12)10-6/h1-3H,(H,10,11,12)
InChIKeyXHDJYQWGFIBCEP-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.370Clc1ccc2NC(=O)C(=O)c2c1
OpenEye OEToolkits 1.7.6c1cc2c(cc1Cl)C(=O)C(=O)N2
ACDLabs 12.01Clc1cc2c(cc1)NC(=O)C2=O
FormulaC8 H4 Cl N O2
Name5-chloro-1H-indole-2,3-dione
ChEMBLCHEMBL327012
DrugBank
ZINCZINC000001722141
PDB chain5g4q Chain B Residue 1375 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5g4q Screening of E. coli beta-clamp Inhibitors Revealed that Few Inhibit Helicobacter pylori More Effectively: Structural and Functional Characterization.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		T175 R177 L178 I248
Binding residue
(residue number reindexed from 1)		T170 R172 L173 I243
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0009360 DNA polymerase III complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5g4q, PDBe:5g4q, PDBj:5g4q
PDBsum5g4q
PubMed29324718
UniProtO25242|DPO3B_HELPY Beta sliding clamp (Gene Name=dnaN)

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