Structure of PDB 5fr2 Chain B Binding Site BS01

Receptor Information
>5fr2 Chain B (length=178) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VNYKPPAQKSIQEIQELDKDDESLRKYKEALLGRVSADPNVPNVVVTRLT
LVCSTAPGPLELDLTGDLESFKKQSFVLKEGVEYRIKISFRVNREIVSGM
KYIQHTYRKGVKIDKTDYMVGSYGPRAEEYEFLTPMEEAPKGMLARGSYN
IKSRFTDDDRTDHLSWEWNLTIKKEWKD
Ligand information
Ligand IDFAR
InChIInChI=1S/C15H26/c1-6-14(4)10-8-12-15(5)11-7-9-13(2)3/h6,9,12H,7-8,10-11H2,1-5H3/b14-6+,15-12+
InChIKeyJXBSHSBNOVLGHF-BUJBXKITSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CC=C(C)CCC=C(C)CCC=C(C)C
OpenEye OEToolkits 1.5.0C\C=C(/C)\CC\C=C(/C)\CCC=C(C)C
CACTVS 3.341C\C=C(C)\CC\C=C(C)\CCC=C(C)C
ACDLabs 10.04C(=C/C)(\CC/C=C(/CC/C=C(\C)C)C)C
FormulaC15 H26
NameFARNESYL
ChEMBL
DrugBank
ZINC
PDB chain5fr2 Chain A Residue 1190 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5fr2 Structural and Mechanistic Insights Into the Regulation of the Fundamental Rho-Regulator Rhogdi Alpha by Lysine Acetylation.
Resolution3.35 Å
Binding residue
(original residue number in PDB)		L77 L86 E87 F102 Y110 I112 Q130
Binding residue
(residue number reindexed from 1)		L51 L60 E61 F76 Y84 I86 Q104
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005094 Rho GDP-dissociation inhibitor activity
GO:0005096 GTPase activator activity
Biological Process
GO:0007266 Rho protein signal transduction
GO:0071526 semaphorin-plexin signaling pathway
Cellular Component
GO:0001772 immunological synapse
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5fr2, PDBe:5fr2, PDBj:5fr2
PDBsum5fr2
PubMed26719334
UniProtP19803|GDIR1_BOVIN Rho GDP-dissociation inhibitor 1 (Gene Name=ARHGDIA)

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