Structure of PDB 5fr1 Chain B Binding Site BS01

Receptor Information
>5fr1 Chain B (length=167) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NYKPPAQKSIQEIQELDKDDESLRKYKEALLVPNVVVTRLTLVCSTAPGP
LELDLTGDLESFKKQSFVLKEGVEYRIKISFRVNREIVSGMKYIQHTYRK
GVKIDKTDYMVGSYGPRAEEYEFLTPMEEAPKGMLARGSYNIKSRFTDDD
RTDHLSWEWNLTIKKEW
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5fr1 Chain B Residue 1203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5fr1 Rhogdi Alpha Acetylation at K127 and K141 Affects Binding Towards Non-Prenylated Rhoa.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		R117 V118 R152
Binding residue
(residue number reindexed from 1)		R82 V83 R117
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005094 Rho GDP-dissociation inhibitor activity
GO:0005096 GTPase activator activity
Biological Process
GO:0007266 Rho protein signal transduction
GO:0071526 semaphorin-plexin signaling pathway
Cellular Component
GO:0001772 immunological synapse
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5fr1, PDBe:5fr1, PDBj:5fr1
PDBsum5fr1
PubMed26695096
UniProtP19803|GDIR1_BOVIN Rho GDP-dissociation inhibitor 1 (Gene Name=ARHGDIA)

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