Structure of PDB 5f5h Chain B Binding Site BS01

Receptor Information
>5f5h Chain B (length=152) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QNPQQLSSNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLV
LFVVQRLEPRFPQASKTSIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEF
RTYEALRREHDSQIVQIAMEAGLRIAPDQWSSLLYGDQSHKSHMQSIIDK
LQ
Ligand information
>5f5h Chain D (length=21) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ccacaccguucuaggugcugg
.<<<<<<......>>>>.>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5f5h Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40.
Resolution2.23 Å
Binding residue
(original residue number in PDB)		R190 R219 S238 K239 T240 Q247 Y250 R251 S253 F255 V257 K259
Binding residue
(residue number reindexed from 1)		R17 R46 S65 K66 T67 Q74 Y77 R78 S80 F82 V84 K86
Binding affinityPDBbind-CN: Kd=81nM
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
External links
PDB RCSB:5f5h, PDBe:5f5h, PDBj:5f5h
PDBsum5f5h
PubMed27010430
UniProtQ4VGL6|RC3H1_MOUSE Roquin-1 (Gene Name=Rc3h1)

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