Structure of PDB 5eel Chain B Binding Site BS01
Receptor Information
>5eel Chain B (length=109) Species:
9606
(Homo sapiens) [
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LSAAIHRTQLWFHGRISREESQRLIGQQGLVDGLFLVRESQRNPQGFVLS
LCHLQKVKHYLILPSEEEGRLYFSMDDGQTRFTDLLQLVEFHQLNRGILP
CLLRHCCTR
Ligand information
>5eel Chain N (length=9) Species:
32630
(synthetic construct) [
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SFEGYDNSg
Receptor-Ligand Complex Structure
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PDB
5eel
Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Resolution
2.47 Å
Binding residue
(original residue number in PDB)
R438 R462 K478 H479 Y480 L481 M495
Binding residue
(residue number reindexed from 1)
R18 R42 K58 H59 Y60 L61 M75
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:5eel
,
PDBe:5eel
,
PDBj:5eel
PDBsum
5eel
PubMed
27257138
UniProt
Q14451
|GRB7_HUMAN Growth factor receptor-bound protein 7 (Gene Name=GRB7)
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