Structure of PDB 5dqo Chain B Binding Site BS01

Receptor Information
>5dqo Chain B (length=154) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLDQIDLLSTKSFPPCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLTLE
QSFNIRHSYTPFSCLKIILSNPPSQGDYHGCPFRHSDPELLKQKLQSYKI
SPGGISQILDLVKGTHYQVACQKYFEMIHNVDDCGFSLNHPNQFFCESQR
ILNG
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain5dqo Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5dqo The [4Fe4S] cluster of human DNA primase functions as a redox switch using DNA charge transport.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		P285 P286 C287 C367 C384 C424 P444
Binding residue
(residue number reindexed from 1)		P14 P15 C16 C64 C81 C121 P141
Annotation score4
Enzymatic activity
Enzyme Commision number 2.7.7.-
Gene Ontology
Biological Process
GO:0006269 DNA replication, synthesis of primer

View graph for
Biological Process
External links
PDB RCSB:5dqo, PDBe:5dqo, PDBj:5dqo
PDBsum5dqo
PubMed28232525
UniProtP49643|PRI2_HUMAN DNA primase large subunit (Gene Name=PRIM2)

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