Structure of PDB 5d1l Chain B Binding Site BS01

Receptor Information
>5d1l Chain B (length=111) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NIPHGQCVICLYGFQEKEAFTKTPCYHYFHCHCLARAIQHMEQELKAQGV
GVQCPVCREPLVYDLASLKAAPEPQQPMELYQPSAESLRQQEERKRLYQR
QQERGGIIDLE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5d1l Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5d1l Insights into Ubiquitination from the Unique Clamp-like Binding of the RING E3 AO7 to the E2 UbcH5B.
Resolution1.618 Å
Binding residue
(original residue number in PDB)		C135 C138 H158 C161
Binding residue
(residue number reindexed from 1)		C7 C10 H30 C33
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0061630 ubiquitin protein ligase activity

View graph for
Molecular Function
External links
PDB RCSB:5d1l, PDBe:5d1l, PDBj:5d1l
PDBsum5d1l
PubMed26475854
UniProtQ96BH1|RNF25_HUMAN E3 ubiquitin-protein ligase RNF25 (Gene Name=RNF25)

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