Structure of PDB 5cve Chain B Binding Site BS01

Receptor Information

>5cve Chain B (length=226) Species: 9606 (Homo sapiens)

GSHMTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISSIDINSSRK
FLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFREVDMVDITEDFL
VQAKTYLGEEGKRVRNYFCCGLQDFTPEPDSYDVIWIQWVIGHLTDQHLA
EFLRRCKGSLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLDVVRRIICSA
GLSLLAEERQENLPDEIYHVYSFALR

Ligand information

>5cve Chain E (length=6) Species: 7227 (Drosophila melanogaster)

PPKTSG

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5cve Molecular basis for histone N-terminal methylation by NRMT1
• Resolution: 1.5 Å
• Binding residue (original residue number in PDB): W20 M30 L31 G32 Y34 W136 D177 D180 E213 I214 Y215
• Binding residue (residue number reindexed from 1): W23 M33 L34 G35 Y37 W139 D180 D183 E216 I217 Y218

Enzymatic activity

• Enzyme Commision number: 2.1.1.244: protein N-terminal methyltransferase.

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008168 methyltransferase activity
• GO:0008276 protein methyltransferase activity
• GO:0042054 histone methyltransferase activity
• GO:0071885 N-terminal protein N-methyltransferase activity

Biological Process

• GO:0006338 chromatin remodeling
• GO:0006480 N-terminal protein amino acid methylation
• GO:0007051 spindle organization
• GO:0007059 chromosome segregation
• GO:0018012 N-terminal peptidyl-alanine trimethylation
• GO:0018013 N-terminal peptidyl-glycine methylation
• GO:0018016 N-terminal peptidyl-proline dimethylation
• GO:0032259 methylation
• GO:0035572 N-terminal peptidyl-serine dimethylation
• GO:0035573 N-terminal peptidyl-serine trimethylation

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:5cve, PDBe:5cve, PDBj:5cve
• PDBsum: 5cve
• PubMed: 26543159
• UniProt: Q9BV86|NTM1A_HUMAN N-terminal Xaa-Pro-Lys N-methyltransferase 1 (Gene Name=NTMT1)