Structure of PDB 5cnx Chain B Binding Site BS01

Receptor Information
>5cnx Chain B (length=360) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STLLASLRDWLKAQQLDAVLLSSRQNKQPHLGISTGSGYVVISRESAHIL
VDSRYYVEVEARAQGYQLHLLDATNTLTTIVNQIIADEQLQTLGFEGQQV
SWETAHRWQSELNAKLVSATPDVLRQIKTPEEVEKIRLACGIADRGAEHI
RRFIQAGMSEREIAAELEWFMRQQGAEKASFDTIVASGWRGALPHGKASD
KIVAAGEFVTLDFGALYQGYCSDMTRTLLVNGEGVSAESHLLFNVYQIVL
QAQLAAISAIRPGVRCQQVDDAARRVITEAGYGDYFGHNTGHAIGIEVHE
DPRFSPRDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTPQGAEVLYA
MPKTVLLTGE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5cnx Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5cnx Structures and activities of widely conserved small prokaryotic aminopeptidases-P clarify classification of M24B peptidases
Resolution2.6 Å
Binding residue
(original residue number in PDB)		D223 H292 E321 E335
Binding residue
(residue number reindexed from 1)		D223 H292 E321 E335
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) H195 D212 D223 T225 H288 H292 H299 E321 Y325 R333 E335
Catalytic site (residue number reindexed from 1) H195 D212 D223 T225 H288 H292 H299 E321 Y325 R333 E335
Enzyme Commision number 3.4.11.-
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008235 metalloexopeptidase activity
GO:0042803 protein homodimerization activity
GO:0046914 transition metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5cnx, PDBe:5cnx, PDBj:5cnx
PDBsum5cnx
PubMed30536999
UniProtP76524|YPDF_ECOLI Aminopeptidase YpdF (Gene Name=ypdF)

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