Structure of PDB 5cd1 Chain B Binding Site BS01

Receptor Information
>5cd1 Chain B (length=321) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HRIRDGDFVVLKREDVFKAVQVQRRKKVTFEKQWFYLDNVIGHSYGTAFE
VTSGGSLQPKTTFRDKTEFAQDKYIKKKKKKYEAIITVVKPSTRILSIMY
YAREPGKINHMRYDTLAQMLTLGNIRAGNKMIVMETCAGLVLGAMMERMG
GFGSIIQLYPGGGPVRAATACFGFPKSFLSGLYEFPLNKVDSLLHGTFSY
IQEKQRRQEEQRKRHLEAAALLSERNADGLIVASRFHPTPLLLSLLDFVA
PSRPFVVYCQYKEPLLECYTKLRERGGVINLRLSETWLRNYQVLPDRSHP
KLLMSGGGGYLLSGFTVAMDN
Ligand information
>5cd1 Chain M (length=74) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggcccggauagcucagucgguagagcaucagacuuaaucugaggguccag
gguucaagucccuguucgggcgcc
.<<<<<<...<<<<........>>>>.<<<<<.....>>>>>.....<<<
<<.......>>>>>.>>>>>>...
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5cd1 Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		R415 V420 L423
Binding residue
(residue number reindexed from 1)		R273 V278 L281
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0006397 mRNA processing
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0031515 tRNA (m1A) methyltransferase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5cd1, PDBe:5cd1, PDBj:5cd1
PDBsum5cd1
PubMed26470919
UniProtQ9UJA5|TRM6_HUMAN tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (Gene Name=TRMT6)

[Back to BioLiP]