Structure of PDB 5c97 Chain B Binding Site BS01

Receptor Information
>5c97 Chain B (length=851) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNIIL
HSTGHNISRVTFMSAEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKIEY
SANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAFKA
TFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAFIV
GEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQYP
LKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKIIA
HELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDFLD
ARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKTYL
SEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTNQTLDVKRMMKTWTLQ
KGFPLVTVQKKGKELFIQQERFFLNTSYLWHIPLSYVTENYSKYQSVSLL
DKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVLS
DKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTDL
IYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSALL
EFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKGW
SFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFRTQKL
SFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYLF
STKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTWW
L
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5c97 Chain B Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5c97 Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing.
Resolution3.37 Å
Binding residue
(original residue number in PDB)		H464 H468 E487
Binding residue
(residue number reindexed from 1)		H301 H305 E324
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) E431 H464 E465 H468 E487 E541 Y549
Catalytic site (residue number reindexed from 1) E268 H301 E302 H305 E324 E378 Y386
Enzyme Commision number 3.4.11.3: cystinyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5c97, PDBe:5c97, PDBj:5c97
PDBsum5c97
PubMed26259583
UniProtQ9UIQ6|LCAP_HUMAN Leucyl-cystinyl aminopeptidase (Gene Name=LNPEP)

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