Structure of PDB 5c7s Chain B Binding Site BS01

Receptor Information

>5c7s Chain B (length=343) Species: 83332 (Mycobacterium tuberculosis H37Rv)

SVPSWPQILGRLTDNRDLARGQAAWAMDQIMTGNARPAQIAAFAVAMTMK
APTADEVGELAGVMLSHAHPLPADTVPDDAVDVVGTGGDGVNTVNLSTMA
AIVVAAAGVPVVKHGNRAASSLSGGADTLEALGVRIDLGPDLVARSLAEV
GIGFCFAPRFHPSYRHAAAVRREIGVPTVFNLLGPLTNPARPRAGLIGCA
FADLAEVMAGVFAARRSSVLVVHGDDGLDELTTTTTSTIWRVAAGSVDKL
TFDPAGFGFARAQLDQLAGGDAQANAAAVRAVLGGARGPVRDAVVLNAAG
AIVAHAGLEWLPAWEEGLRRASAAIDTGAAEQLLARWVRFGRQ

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 5c7s Chain B Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5c7s Binding and mimicking of the phosphate-rich substrate, PRPP
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): D251 E252
• Binding residue (residue number reindexed from 1): D229 E230
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): V106
• Catalytic site (residue number reindexed from 1): V84
• Enzyme Commision number: 2.4.2.18: anthranilate phosphoribosyltransferase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004048 anthranilate phosphoribosyltransferase activity
• GO:0016757 glycosyltransferase activity
• GO:0016763 pentosyltransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000162 tryptophan biosynthetic process

Cellular Component

• GO:0005576 extracellular region
• GO:0005829 cytosol
• GO:0005886 plasma membrane

External links

• PDB: RCSB:5c7s, PDBe:5c7s, PDBj:5c7s
• PDBsum: 5c7s
• UniProt: P9WFX5|TRPD_MYCTU Anthranilate phosphoribosyltransferase (Gene Name=trpD)