Structure of PDB 5c2y Chain B Binding Site BS01

Receptor Information
>5c2y Chain B (length=168) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGMATIEDIKETALIPFQKHRQLSMHEAEVITLEIIGLLCDSECKDEKTL
KYLGRFLTPDMYQDLVDERNLNKRCGYPLCGKSPERIRDPFSMNDTTKKF
LLENNPYAYLSHYCSKFHFRCSQFYQVQLSDEALFARTGVHLFEDPEQDK
HDIDFKVTLFEELLREKA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5c2y Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5c2y Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		C73 C78 C112 H116
Binding residue
(residue number reindexed from 1)		C75 C80 C114 H118
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity
GO:0043175 RNA polymerase core enzyme binding

View graph for
Molecular Function
External links
PDB RCSB:5c2y, PDBe:5c2y, PDBj:5c2y
PDBsum5c2y
PubMed26933063
UniProtP40084|RTR1_YEAST RNA polymerase II subunit B1 CTD phosphatase RTR1 (Gene Name=RTR1)

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