Structure of PDB 5c1z Chain B Binding Site BS01

Receptor Information

>5c1z Chain B (length=384) Species: 9606 (Homo sapiens)

MIVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKEL
RNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATNSFYVYCKGPCQRVQPG
KLRVQCSTCRQATLTLTQGPSCWDDVLIPNRMSGECQSPHCPGTSAEFFF
KCGAHPTSDKETSVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVIC
LDCFHLYCVTRLNDRQFVHDPQLGYSLPCVAGCPNSLIKELHHFRILGEE
QYNRYQQYGAEECVLQMGGVLCPRPGCGAGLLPEPDQRKVTCEGNGFAFC
RECKEAYHEGECSAVFEYRVDERAAEQARWEATTKPCPRCHVPVEKNGGC
MHMKCPQPQCRLEWCWNCGCEWNRVCMGDHWFDV

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 5c1z Chain B Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5c1z Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
• Resolution: 1.79 Å
• Binding residue (original residue number in PDB): C150 C154 C212 H215
• Binding residue (residue number reindexed from 1): C90 C94 C152 H155
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 2.3.2.31: RBR-type E3 ubiquitin transferase.

Gene Ontology

Molecular Function

• GO:0004842 ubiquitin-protein transferase activity
• GO:0008270 zinc ion binding

Biological Process

• GO:0016567 protein ubiquitination

Cellular Component

• GO:0005739 mitochondrion
• GO:0005829 cytosol

External links

• PDB: RCSB:5c1z, PDBe:5c1z, PDBj:5c1z
• PDBsum: 5c1z
• PubMed: 26254304
• UniProt: O60260|PRKN_HUMAN E3 ubiquitin-protein ligase parkin (Gene Name=PRKN)