Structure of PDB 5b56 Chain B Binding Site BS01

Receptor Information

>5b56 Chain B (length=432) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISL
LASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLST
LACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLAD
SCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNI
VTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQI
QQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCG
IIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGL
DKIEALQRHENESVYKASLNLIEKYFSVEEEE

Ligand information

>5b56 Chain D (length=12) Species: 401671 (HIV-1 M:B_89.6) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

QQRRTRNGASKS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5b56 Molecular Mechanism of HIV-1 Vpr for Binding to Importin-alpha
Resolution	2.3 Å
Binding residue (original residue number in PDB)	G281 R315 N319 V321 T322 G323 D325 T328 E354 W357 N361 A364 G365 E396 W399 N403 G407
Binding residue (residue number reindexed from 1)	G211 R245 N249 V251 T252 G253 D255 T258 E284 W287 N291 A294 G295 E326 W329 N333 G337

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Cellular Component

External links

PDB	RCSB:5b56, PDBe:5b56, PDBj:5b56
PDBsum	5b56
PubMed	27181198
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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