Structure of PDB 5aor Chain B Binding Site BS01

Receptor Information
>5aor Chain B (length=992) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVIDRIQEQRDMNEAEAFDVNAAIHGNWTIENAKERLNIYKQTNNIRDDY
KYTPVGPEHARSFLAELSIYVPALNRTVTARESGSNKKSASKSCALSLVR
QLFHLNVIEPFSGTLKKKKDEQLKPYPVKLSPNLINKIDEVIKGLDLPVV
NPRNIKIELGPPIPLIVSVIPWAPPQANWNTWHACSIDDLSMDYERSLRD
RRQNDNEYRQFLEFREKLPIAAMRSEILTAINDNPVVIIRGNTGCGKTTQ
IAQYILDDYICSGQGGYANIYVTQPRRISAISVAERVARERCEQLGDTVG
YSVRFESVFPRPYGAILFCTVGVLLRKLEAGLRGVSHIIVDEIHERDVNS
DFLLVILRDMVDTYPDLHVILMSATIDTTKFSKYFGICPVLEVPGRAFPV
QQFFLEDIIQMTDFVPSAESRRKRKEVEDEEQLLSEDKDEAEINYNKVCE
DKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAILVFLPGWNLI
FALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVPEGVTKIILS
TNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWASKTNLEQRK
GRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMALTIKLLRLGS
IHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGRLLARLPIEP
RLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRLANHQKALSG
TKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTMNVIWDAKQQ
LLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLGLYPNICVHK
EKRKVLTTESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIRTRAVSCKQL
SMVSPLQVILFGSRKIDLAANNIVRVDNWLNFDIEPELAAKIGALKPALE
DLITVACDNPSDILRLEEPYAQLVKVVKDLCVKSAGDFGLQR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5aor Structure of the RNA Helicase Mle Reveals the Molecular Mechanisms for Uridine Specificity and RNA-ATP Coupling.
Resolution2.08 Å
Binding residue
(original residue number in PDB)		H196 A197 R442 R443 R470 T486 V489 R492 K589 V635 F637 G662 W663 N664 A668 H691 S692 Q693 T717 N718 I719 R739 Y752 R861 P863 F894 E896 S899 L900 Q953 Q966 K1033 T1034 T1058
Binding residue
(residue number reindexed from 1)		H59 A60 R276 R277 R304 T320 V323 R326 K423 V469 F471 G496 W497 N498 A502 H525 S526 Q527 T551 N552 I553 R573 Y586 R695 P697 F728 E730 S733 L734 Q787 Q800 K867 T868 T892
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0001069 regulatory region RNA binding
GO:0003676 nucleic acid binding
GO:0003678 DNA helicase activity
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003725 double-stranded RNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0033679 3'-5' DNA/RNA helicase activity
GO:0034458 3'-5' RNA helicase activity
GO:0043138 3'-5' DNA helicase activity
GO:0106222 lncRNA binding
Biological Process
GO:0007549 sex-chromosome dosage compensation
GO:0008340 determination of adult lifespan
GO:0009047 dosage compensation by hyperactivation of X chromosome
GO:0010468 regulation of gene expression
GO:0031453 positive regulation of heterochromatin formation
GO:0032508 DNA duplex unwinding
GO:0042714 dosage compensation complex assembly
GO:0045433 male courtship behavior, veined wing generated song production
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048675 axon extension
GO:0050684 regulation of mRNA processing
GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
GO:2000765 regulation of cytoplasmic translation
Cellular Component
GO:0000228 nuclear chromosome
GO:0000785 chromatin
GO:0000805 X chromosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0016456 X chromosome located dosage compensation complex, transcription activating
GO:0072487 MSL complex
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5aor, PDBe:5aor, PDBj:5aor
PDBsum5aor
PubMed26545078
UniProtP24785|MLE_DROME Dosage compensation regulator mle (Gene Name=mle)

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