Structure of PDB 5ah4 Chain B Binding Site BS01

Receptor Information
>5ah4 Chain B (length=380) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TDLKFRVVREDFADAVAWVARSLPTRIPVLAGVLLTGTDEGLTISGFDYE
VSAEVKVSAEIASAGSVLVSGRLLSDITKALPAKPVEVSVEGTRVSLTCG
SARFSLPTLAVEDYPALPALPEETGVIASDLFAEAIGQVAVAAGRDDTLP
MLTGIRVEISGESVVLAATDRFRLAVRELTWVTTAGDVEAAVLVPAKTLA
EAAKAGTNQVHLALGSGASVGKDGLLGIRSEGKRSTTRLLDAEFPKFRQL
LPAEHTAVATIGVAELTEAIKRVALVADRGAQIRMEFSDDTLKLSAGADD
VGRAEEDLPVDFAGEPLTIAFNPTYLTDGLGSLHSERVTFGFTTPSRPAV
LRPAGEDGGSGPFPAAKTDYVYLLMPVRLP
Ligand information
Receptor-Ligand Complex Structure
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PDB5ah4 Antibiotics. Targeting Dnan for Tuberculosis Therapy Using Novel Griselimycins.
Resolution2.313 Å
Binding residue
(original residue number in PDB)		L159 R181
Binding residue
(residue number reindexed from 1)		L149 R171
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0046677 response to antibiotic
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0009360 DNA polymerase III complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ah4, PDBe:5ah4, PDBj:5ah4
PDBsum5ah4
PubMed26045430
UniProtA0QND6|DPO3B_MYCS2 Beta sliding clamp (Gene Name=dnaN)

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