Structure of PDB 5afq Chain B Binding Site BS01

Receptor Information

>5afq Chain B (length=444) Species: 9606 (Homo sapiens)

MTQAEIKLCSLLLQEHFGEIVEKIGVHLIRTGSQPLRVIAHDTGTSLDQV
KKALCVLVQHNLVSYQVHKRGVVEYEAQCSRVLRMLRYPRYIYTTKTLYS
DTGELIVEELLLNGKLTMSAVVKKVADRLTETMEDGKTMDYAEVSNTFVR
LADTHFVQRCPSVDGIYWQANLDRFHQHFRDQAIVSAVANRMDQTSSEIV
RTMLRMSEITTSSSAPFTQPLSSNEIFRSLPVGYNISKQVLDQYLTLLAD
DPLEFVGKSGDSGGGMYVINLHKALASLATATLESVVQERFGSRCARIFR
LVLQKKHIEQKQVEDFAMIPAKEAKDMLYKMLSENFMVNILSAARMLLHR
CYKSIANLIERRQFETKENKRLLEKSQRVEAIIASMQATGAEEAQLQEIE
EMITAPERQQLETLKRNVNKLDASEIQVDETIFLLESYIECTMK

Ligand information

>5afq Chain E (length=19) Species: 9606 (Homo sapiens)

AAAAAAAAAAAAAAAAAAA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5afq Structural Analysis of Human Rpc32Beta - Rpc62 Complex.
• Resolution: 7.0 Å
• Binding residue (original residue number in PDB): H16 Y93 D510
• Binding residue (residue number reindexed from 1): H16 Y93 D422

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003697 single-stranded DNA binding
• GO:0003899 DNA-directed 5'-3' RNA polymerase activity
• GO:0005515 protein binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0006359 regulation of transcription by RNA polymerase III
• GO:0032728 positive regulation of interferon-beta production
• GO:0045087 innate immune response
• GO:0045089 positive regulation of innate immune response
• GO:0051607 defense response to virus

Cellular Component

• GO:0000428 DNA-directed RNA polymerase complex
• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005666 RNA polymerase III complex
• GO:0005829 cytosol

External links

• PDB: RCSB:5afq, PDBe:5afq, PDBj:5afq
• PDBsum: 5afq
• PubMed: 26394183
• UniProt: Q9BUI4|RPC3_HUMAN DNA-directed RNA polymerase III subunit RPC3 (Gene Name=POLR3C)