Structure of PDB 5a86 Chain B Binding Site BS01

Receptor Information
>5a86 Chain B (length=274) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVSREEAAKWSQVRK
DLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGI
ISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRL
SYCLEDGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVL
QHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQH
TQRLLRIQDIHPFATPLMQELFGI
Ligand information
Receptor-Ligand Complex Structure
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PDB5a86 Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity.
Resolution2.25 Å
Binding residue
(original residue number in PDB)		I255 K259 I269 K277 P423 L424 E427
Binding residue
(residue number reindexed from 1)		I101 K105 I115 K123 P266 L267 E270
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5a86, PDBe:5a86, PDBj:5a86
PDBsum5a86
PubMed26291341
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2)

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