Structure of PDB 4zri Chain B Binding Site BS01

Receptor Information
>4zri Chain B (length=291) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKD
TVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL
QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLP
KRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVN
YFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKE
FTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4zri Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway
Resolution2.7 Å
Binding residue
(original residue number in PDB)		E136 V139 L176 Y177 M179 R187 W191 E206 K209 I210
Binding residue
(residue number reindexed from 1)		E116 V119 L156 Y157 M159 R167 W171 E186 K189 I190
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0008092 cytoskeletal protein binding
Cellular Component
GO:0005856 cytoskeleton

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Molecular Function
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Cellular Component
External links
PDB RCSB:4zri, PDBe:4zri, PDBj:4zri
PDBsum4zri
PubMed26045165
UniProtP35240|MERL_HUMAN Merlin (Gene Name=NF2)

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