Structure of PDB 4zr0 Chain B Binding Site BS01

Receptor Information
>4zr0 Chain B (length=270) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILRSDFKKDFY
VDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLPVVVYHMGVALK
NMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFLLH
GCHHYLPMDKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGLFG
YVCYDECHFFLHHSKLPPFMRKLKKYHLEHHYKNYQLGFGVTSWFWDEVF
GTYLGPDAPLSKMKYESGLE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4zr0 Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4zr0 The Crystal Structure of an Integral Membrane Fatty Acid alpha-Hydroxylase.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		H271 H326 H330 H345 H349
Binding residue
(residue number reindexed from 1)		H153 H208 H212 H227 H231
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.18.6: 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase.
1.14.18.7: dihydroceramide fatty acyl 2-hydroxylase.
Gene Ontology
Molecular Function
GO:0000170 sphingosine hydroxylase activity
GO:0005506 iron ion binding
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0080132 fatty acid 2-hydroxylase activity
GO:0102771 dihydroceramide fatty acyl 2-hydroxylase activity
GO:0120521 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase activity
Biological Process
GO:0000038 very long-chain fatty acid metabolic process
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006673 inositol phosphoceramide metabolic process
GO:0008610 lipid biosynthetic process
GO:0044255 cellular lipid metabolic process
GO:0046513 ceramide biosynthetic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zr0, PDBe:4zr0, PDBj:4zr0
PDBsum4zr0
PubMed26515067
UniProtQ03529|SCS7_YEAST Ceramide very long chain fatty acid hydroxylase SCS7 (Gene Name=SCS7)

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