Structure of PDB 4zpk Chain B Binding Site BS01

Receptor Information
>4zpk Chain B (length=321) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KRSSSELRKEKSRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIM
RLAISFLRTHKLLSSVCSENESEAEADQQMDNLYLKALEGFIAVVTQDGD
MIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLTLSTERDFFM
RMKCTVTNRGRTVNLKSATWKVLHCTGQVRVYNLSCLIIMCEPIQHPSHM
DIPLDSKTFLSRHSMDMKFTYCDDRILELIGYHPEELLGRSAYEFYHALD
SENMTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNLQPQCIM
CVNYVLSEIKNDVVFSMDQTE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4zpk Structural integration in hypoxia-inducible factors.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		K18 R26 N184 K186
Binding residue
(residue number reindexed from 1)		K11 R19 N164 K166
Binding affinityPDBbind-CN: Kd=45nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zpk, PDBe:4zpk, PDBj:4zpk
PDBsum4zpk
PubMed26245371
UniProtP97481|EPAS1_MOUSE Endothelial PAS domain-containing protein 1 (Gene Name=Epas1)

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