Structure of PDB 4znx Chain B Binding Site BS01

Receptor Information

>4znx Chain B (length=56) Species: 9606 (Homo sapiens)

LFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPS
NYVAPV

Ligand information

>4znx Chain F (length=10) Species: 32630 (synthetic construct)

APPLPPRNRP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4znx The role of water molecules in the binding of class I and II peptides to the SH3 domain of the Fyn tyrosine kinase.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): Y91 Y93 D100 E116 G117 D118 W119 P134 N136 Y137
• Binding residue (residue number reindexed from 1): Y6 Y8 D15 E31 G32 D33 W34 P49 N51 Y52

Enzymatic activity

• Enzyme Commision number: 2.7.10.2: non-specific protein-tyrosine kinase.

External links

• PDB: RCSB:4znx, PDBe:4znx, PDBj:4znx
• PDBsum: 4znx
• PubMed: 27599862
• UniProt: P06241|FYN_HUMAN Tyrosine-protein kinase Fyn (Gene Name=FYN)