Structure of PDB 4zng Chain B Binding Site BS01

Receptor Information

>4zng Chain B (length=360) Species: 1358 (Lactococcus lactis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SKIERISAFLNDKEVDMTFITNPTTLNYLTGLAIDPHERIAGLMIFRDST
PMLFTPALEVEKAKEHTSGLDIFGYEDSQNPWEVVKNHVKSDVKSIAVEF
SDIPLAKTEGLKAQFGDINFVNLTPLIERMRLIKSADEIEKMKVAGDFAD
KCFEIGFATAAERNGVTESDIVAKIEYEMKRMGVPQMSFDTLVLSGARAA
NPHGAPENVEIQENKLLLFDLGVMSGGYASDATRTIAIGQPNDFDAEIHK
IVKEAQQAAMDFIKPGVTAHEVDAVARDLITKAGYGEYFNHRLGHGIGMD
VHEYPSIVAGNDLVIQEGMCFSNEPGIYIPGKVGVRIEDCLYVTENGCES
FTHTDHDLLI

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

4zng Chain B Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4zng X-ray crystallography of recombinant Lactococcus lactis prolidase
Resolution	2.25 Å
Binding residue (original residue number in PDB)	D221 D232 E339
Binding residue (residue number reindexed from 1)	D220 D231 E338
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	H204 D221 D232 T234 H292 H296 H303 E325 Y329 R337 E339
Catalytic site (residue number reindexed from 1)	H203 D220 D231 T233 H291 H295 H302 E324 Y328 R336 E338
Enzyme Commision number	3.4.13.9: Xaa-Pro dipeptidase.

Gene Ontology

	Molecular Function
GO:0004177	aminopeptidase activity
GO:0016805	dipeptidase activity
GO:0046872	metal ion binding
GO:0102009	proline dipeptidase activity

View graph for
Molecular Function

External links

PDB	RCSB:4zng, PDBe:4zng, PDBj:4zng
PDBsum	4zng
PubMed
UniProt	A8WBX8

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