Structure of PDB 4zdo Chain B Binding Site BS01

Receptor Information
>4zdo Chain B (length=458) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NRESFAAGERLYVRQGCEARRSHEHLIRLLLEKGKCPENGWDESTLELFL
HELAIMDSNNFLGNCGVGEREGRVASALVARRHYRFIHGIGRSGDISAVQ
PKAAGSSLLNKITNSLVLDIIKLAGVHTVANCFVVPMATGMSLTLCFLTL
RHKRPKAKYIIWPRIDQKSCFKSMITAGFEPVVIENVLEGDELRTDLKAV
EAKVQELGPDCILCIHSTTSCFAPRVPDRLEELAVICANYDIPHIVNNAY
GVQSSKCMHLIQQGARVGRIDAFVQSLDKNFMVPVGGAIIAGFNDSFIQE
ISKMYPGRASASPSLDVLISLLSLGSNGYKKLLKERKEMFSYLSNQIKKL
SEAYNERLLHTPHNPISLAMTLKTLDEHRDKAVTQLGSMLFTRQVSGARV
VPLGSMQTVSGYTFRGFMSHTNNYPCAYLNAASAIGMKMQDVDLFIKRLD
RCLKAVRK
Ligand information
>4zdo Chain E (length=75) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcccggaugauccucaguggucuggggugcagaccuguugucucgacaga
gugguucaauuccaccuuucgggcg
<<<<<<<....<<<<<<....>>>>>>.<<<....>>><<<<..>>>>..
<<<<.......>>>>..>>>>>>>.
Receptor-Ligand Complex Structure
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PDB4zdo Structural basis for early-onset neurological disorders caused by mutations in human selenocysteine synthase.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		S393 M394 T397 R398 Q399
Binding residue
(residue number reindexed from 1)		S388 M389 T392 R393 Q394
Enzymatic activity
Catalytic site (original residue number in PDB) R75 R97 S98 Q105 Q172 A254 K284 R313
Catalytic site (residue number reindexed from 1) R70 R92 S93 Q100 Q167 A249 K279 R308
Enzyme Commision number 2.9.1.2: O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0098621 O-phosphoseryl-tRNA(Sec) selenium transferase activity
Biological Process
GO:0001514 selenocysteine incorporation
GO:0001717 conversion of seryl-tRNAsec to selenocys-tRNAsec
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zdo, PDBe:4zdo, PDBj:4zdo
PDBsum4zdo
PubMed27576344
UniProtQ9HD40|SPCS_HUMAN O-phosphoseryl-tRNA(Sec) selenium transferase (Gene Name=SEPSECS)

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