Structure of PDB 4zc0 Chain B Binding Site BS01

Receptor Information
>4zc0 Chain B (length=434) Species: 210 (Helicobacter pylori) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TMDHLKHLQQLQNIERIVLSGIVLANHKIEEVHSVLEPSDFYYPPNGLFF
EIALKLHEEDCPIDENFIRQKMPKDKQIKEEDLVAIFAASPIDNIEAYVE
EIKNASIKRKLFGLANTIREQALESKSSDILGAVEREVYALLNGSTIEGF
RNIKEVLESAMDLITENQRVTGIPTGFVQLDNYTSGFNKGSLVIIGARPS
MGKTSLMMNMVLSALNDDRGVAVFSLEMSAEQLALRALSDLTSINMHDLE
SGRLDDDQWENLAKCFDHLSQKKLFFYDKSYVRIEQIRLQLRKLKSQHKE
LGIAFIDYLQLMQIAEISRELKTLARELEIPIIALVQLNRSLENRDDKRP
ILSDIKGGIEQDADIVLFLYRGYIYQMRAEDNKIDKLKKEEERRIHKQNG
SIEEAEIIVAKNRNGATGTVYTRFNAPFTRYEDM
Ligand information
Ligand IDTBR
InChIInChI=1S/12BrH.6Ta/h12*1H;;;;;;/q;;;;;;;;;;;;;;;;;+1/p-1
InChIKeyYWYIQTPPCOBSGN-UHFFFAOYSA-M
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0Br[Ta]123456Br[Ta]17891%10[Ta]22%11(Br7)[Ta]337%12%13([Ta]484([Ta]923(Br%11)(Br1)(Br4)(Br7)Br%12)(Br5)(Br%10)Br%13)Br6
CACTVS 3.370Br|1[Ta]|2|3|4|5|Br[Ta]|6|7|89%10|2|Br[Ta]|%11|%12|%13|%14|1|3|6Br|[Ta]|%15|%16|%17|7|%11(Br|[Ta]|%18|4|%12|%15(Br|%13)(Br|%14)|Br[Ta]|5|8|%16|%18(|Br9)(Br)Br|%17)|Br%10
FormulaBr12 Ta6
NameHEXATANTALUM DODECABROMIDE;
DODECABROMOHEXATANTALUM
ChEMBL
DrugBankDB04119
ZINC
PDB chain4zc0 Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4zc0 Structure and primase-mediated activation of a bacterial dodecameric replicative helicase.
Resolution6.7 Å
Binding residue
(original residue number in PDB)		P37 S38 P43 L47 E50
Binding residue
(residue number reindexed from 1)		P38 S39 P44 L48 E51
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016853 isomerase activity
GO:0016887 ATP hydrolysis activity
GO:0042802 identical protein binding
GO:0043139 5'-3' DNA helicase activity
Biological Process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006269 DNA replication, synthesis of primer
Cellular Component
GO:0005829 cytosol
GO:1990077 primosome complex

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4zc0, PDBe:4zc0, PDBj:4zc0
PDBsum4zc0
PubMed26264665
UniProtO25916|DNAB_HELPY Replicative DNA helicase DnaB (Gene Name=dnaB)

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