Structure of PDB 4z3o Chain B Binding Site BS01

Receptor Information
>4z3o Chain B (length=689) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAK
AKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHI
QTLLLTFFYRYMRPLVEAGHVYIALPPLYKMAYAWTDGELEELRKQRYKG
LGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKW
IEDNVKFTIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRIL
YSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNR
EILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNF
DDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMID
HPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIE
KLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDG
LRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPI
LSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRAS
ENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREK
IAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED
Ligand information
Receptor-Ligand Complex Structure
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PDB4z3o Structural studies of the drug-stabilized cleavage complexes of topoisomerase IV and gyrase from Streptococcus pneumoniae
Resolution3.44 Å
Binding residue
(original residue number in PDB)		E433 K458 D510 R1028 K1038 V1040 H1074 H1076 R1087 K1093 T1168 I1170
Binding residue
(residue number reindexed from 1)		E19 K44 D96 R233 K243 V245 H279 H281 R292 K298 T373 I375
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4z3o, PDBe:4z3o, PDBj:4z3o
PDBsum4z3o
PubMed
UniProtP72525|PARC_STRPN DNA topoisomerase 4 subunit A (Gene Name=parC);
Q59961|PARE_STRPN DNA topoisomerase 4 subunit B (Gene Name=parE)

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