Structure of PDB 4z17 Chain B Binding Site BS01

Receptor Information
>4z17 Chain B (length=420) Species: 324602 (Chloroflexus aurantiacus J-10-fl) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
STLIEAIVAREVLDSRGNPTIEVDVRLESGDVGRAIVPSGASTGAHEALE
LRDGDKSRYNGKGVLKAVQAVNEDIAEALIGFDAADQIALDQELIALDGT
PNKSKLGANAILGVSLAAAKAAAAAFGLPLYRYLGGVYAHVLPVPMMNIM
NGGQHAFQEFMIMPVGAESFREGLRWGAEIYHMLKKVIHDRGFSTTVGDE
GGFAPSLPTNDAPLQLIMEAIEKAGYRPGEQIVIALDPATTEIFEDGKYH
LKREGRSLSSAEMVDYWVDLVNRYPIISLEDGLAEDDWEGWALLRAKLGD
RVQLVGDDFLVTNVQRLQRAIEAKAANSILIKLNQIGSLTETLSAIQLAQ
RSGWTAVVSHRSGESEDVTIADLVVATNAGQIKTGAPARTDRIAKYNQLL
RIEEELGSAARYAGRSAFKV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4z17 Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4z17 Biochemical and Structural Characterization of Enolase from Chloroflexus aurantiacus: Evidence for a Thermophilic Origin.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		D243 D313
Binding residue
(residue number reindexed from 1)		D237 D307
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) S43 H156 E165 E206 D243 E286 D313 K338 H366 K389
Catalytic site (residue number reindexed from 1) S42 H155 E159 E200 D237 E280 D307 K332 H360 K383
Enzyme Commision number 4.2.1.11: phosphopyruvate hydratase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0006096 glycolytic process
Cellular Component
GO:0000015 phosphopyruvate hydratase complex
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0009986 cell surface

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4z17, PDBe:4z17, PDBj:4z17
PDBsum4z17
PubMed26082925
UniProtA9WCM4|ENO_CHLAA Enolase (Gene Name=eno)

[Back to BioLiP]