Structure of PDB 4ywl Chain B Binding Site BS01

Receptor Information
>4ywl Chain B (length=254) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SVDREEMIERFANFLREYTDEDGNPVYRGKITDLLTITPKRSVAIDWMHL
NSFDSELAHEVIENPEEGISAAEDAIQIVLREDFQREDVGKIHARFYNLP
ETLMVKDIGAEHINKLIQVEGIVTRVGEIKPFVSVAVFVCKDCGHEMIVP
QKPYESLEKVKKCEQCGSKNIELDVNKSSAVNFQSFRIQDRPETLKGGEM
PRFIDGILLDDIVDVALPGDRVIVTGILRVVLEKREKTPIFRKILEVNHI
EPVS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4ywl Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4ywl MCM ring hexamerization is a prerequisite for DNA-binding.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		C139 C142 C162 C165
Binding residue
(residue number reindexed from 1)		C140 C143 C163 C166
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005524 ATP binding
Biological Process
GO:0032508 DNA duplex unwinding

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Molecular Function
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Biological Process
External links
PDB RCSB:4ywl, PDBe:4ywl, PDBj:4ywl
PDBsum4ywl
PubMed26365238
UniProtQ8U3I4

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