Structure of PDB 4ypi Chain B Binding Site BS01

Receptor Information
>4ypi Chain B (length=347) Species: 128952 (Ebola virus - Mayinga, Zaire, 1976) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RVIPVYQVNNLEEICQLIIQAFEAGVDFQESADSFLLMLCLHHAYQGDYK
LFLESGAVKYLEGHGFRFEVKKRDGVKRLEELLPAVSSGKNIKRTLAAMP
EEETTEANAGQFLSFASLFLPKLVVGEKACLEKVQRQIQVHAEQGLIQYP
TAWQSVGHMMVIFRLMRTNFLIKFLLIHQGMHMVAGHDANDAVISNSVAQ
ARFSGLLIVKTVLDHILQKTERGVRLHPLARTAKVKNEVNSFKAALSSLA
KHGEYAPFARLLNLSGVNNLEHGLFPQLSAIALGVATAHGSTLAGVNVGE
QYQQLREAATEAEKQLQQYAESRELDHLGLDDQEKKILMNFHQKKNE
Ligand information
>4ypi Chain F (length=28) Species: 128952 (Ebola virus - Mayinga, Zaire, 1976) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MPGPELSGWISEQLMTGRIPVSDIFCDI
Receptor-Ligand Complex Structure
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PDB4ypi An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions.
Resolution3.71 Å
Binding residue
(original residue number in PDB)		R240 F241 K248 D252 H253 L255 Q256 K257 L264 R269 K274 K281 L284 L287 A288 G291 E292 A294 H327 Q355 A358 E359
Binding residue
(residue number reindexed from 1)		R202 F203 K210 D214 H215 L217 Q218 K219 L226 R231 K236 K243 L246 L249 A250 G253 E254 A256 H289 Q317 A320 E321
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0019074 viral RNA genome packaging
Cellular Component
GO:0019013 viral nucleocapsid

View graph for
Biological Process
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Cellular Component
External links
PDB RCSB:4ypi, PDBe:4ypi, PDBj:4ypi
PDBsum4ypi
PubMed25865894
UniProtP18272|NCAP_EBOZM Nucleoprotein (Gene Name=NP)

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