Structure of PDB 4y6l Chain B Binding Site BS01

Receptor Information
>4y6l Chain B (length=273) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRLPYPEAI
FEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQN
IDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVT
PKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQP
FASLISKAPLSTPRLLINKEKAGGMDFDSKKAYRDVAWLGECDQGCLALA
ELLGWKKELEDLVRREHASIDAQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4y6l Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		F96 R97 F131 A135 F143 H187 V233 F235 G236 E237 F244 Q265 V266 Q267 P268
Binding residue
(residue number reindexed from 1)		F42 R43 F63 A67 F75 H119 V165 F167 G168 E169 F176 Q197 V198 Q199 P200
Enzymatic activity
Catalytic site (original residue number in PDB) P94 D95 F96 R97 N168 D170 H187
Catalytic site (residue number reindexed from 1) P40 D41 F42 R43 N100 D102 H119
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:4y6l, PDBe:4y6l, PDBj:4y6l
PDBsum4y6l
PubMed25897714
UniProtQ8IXJ6|SIR2_HUMAN NAD-dependent protein deacetylase sirtuin-2 (Gene Name=SIRT2)

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