Structure of PDB 4xww Chain B Binding Site BS01

Receptor Information

>4xww Chain B (length=543) Species: 1299 (Deinococcus radiodurans)

APTLEVIPLGGMGEIGKNITVFRYGDEIVVVDGGLAFPKAHQMGIDLIVP
RIDYLLEHQDKIKGWILTHGHEDHIGGLPYIFARLPRVPVYGLPLTLALV
REKLSEFGLQDVDLREVTYGDEVRFGQSFVAEFFCMTHSIPDNAGYILKT
PVGDVLHTGDFKIDPDVGTGAGIVSDLERVEQAGKDGVLLLISDSTNAER
PGHTPSEAEIARNLEEIIKGCRGRVFLTTFASQVYRIQNILDLAHRQGRR
VVMEGRSMIKYAQAAQATGHMNPPEPFLTSEEVGELQDQQVLFVCTGSQG
QPMAVLGRLAFGTHAKIALRRGDTVILSSNPIPGNEDAVNLIVNRLYEIG
VDVVYPPTYRVHASGHASQEELATILNLTRPKFFLPWHGEPRHQINHAKL
AQTLPRPPKRTLIAKNGDIVNLGPDEFRVSGTVAAGAVYVDGLGVGDVND
DVLLDRVNLSQEGLLILTAVLHPTPHVEVVARGFARPNRDLELQIRRVAL
EAVEQGLREKKRLEDVRDDMYGAVRRFTRKATGRNPVLIPMIV

Ligand information

>4xww Chain E (length=7)

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.......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4xww Structural insights into catalysis and dimerization enhanced exonuclease activity of RNase J
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): I30 F52 H86 E87 D88 F245 A246 S247 R271 S272 T311 Q316 M318 R323 I347 P348 S379 G380 H381
• Binding residue (residue number reindexed from 1): I15 F37 H71 E72 D73 F230 A231 S232 R256 S257 T296 Q301 M303 R308 I332 P333 S364 G365 H366

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0004521 RNA endonuclease activity
• GO:0004527 exonuclease activity
• GO:0004534 5'-3' RNA exonuclease activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006364 rRNA processing
• GO:0006396 RNA processing

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4xww, PDBe:4xww, PDBj:4xww
• PDBsum: 4xww
• PubMed: 25940620
• UniProt: H9CZL7