Structure of PDB 4x7u Chain B Binding Site BS01

Receptor Information

>4x7u Chain B (length=252) Species: 28040 (Micromonospora griseorubida) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PSTGVELYLDLLKRTVSNFIYQDATHVAGLITEAAFVEEARESGEDYPTV
AHTMIGMKRLNNLQHCVESALRDGVPGDVLETGVWRGGACIFARGILKAY
DVRDRTVWVADSFQGFPKITDDDHPMDAEMNLHQYNEAVDLPTSLATVQR
NFSRYGLLDDQVRFLPGWFKDTMPTAPFERLAVLRMDGDSYGATMDVLTH
AYPRLSPGGFAIIDDYCIPACREAVHEYRDRHGISDEIVEIDRQGVYWRR
SA

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

4x7u Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	4x7u Structural Basis of Substrate Specificity and Regiochemistry in the MycF/TylF Family of Sugar O-Methyltransferases.
Resolution	1.65 Å
Binding residue (original residue number in PDB)	D189 D216 D217
Binding residue (residue number reindexed from 1)	D187 D214 D215
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.1.1.237: mycinamicin III 3''-O-methyltransferase.

Gene Ontology

	Molecular Function
GO:0000287	magnesium ion binding
GO:0008168	methyltransferase activity
GO:0008171	O-methyltransferase activity
GO:0036094	small molecule binding
GO:0046872	metal ion binding

	Biological Process
GO:0017000	antibiotic biosynthetic process
GO:0032259	methylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:4x7u, PDBe:4x7u, PDBj:4x7u
PDBsum	4x7u
PubMed	25692963
UniProt	Q49492\|MYCF_MICGR Mycinamicin III 3''-O-methyltransferase (Gene Name=mycF)

[Back to BioLiP]