Structure of PDB 4x33 Chain B Binding Site BS01

Receptor Information
>4x33 Chain B (length=325) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SCVYAFGSNGQRQLGLGHDEDMDTPQRSVPGAIVRKIACGGNHSVMLTND
GNLVGCGDNRRGELDSAQALRQVHDWRPVEVPAPVVDVACGWDTTVIVDA
DGRVWQRGGGCYEFTQQHVPLNSNDERIAVYGCFQNFVVVQGTRVYGWGS
NTKCQLQEPKSRSLKEPVLVYDTGSVAVDYVAMGKDFMVIVDEGGRIVHA
SGRLPTGFELKQQQKRHNLVVLCMWTSIHLWNARLNTVESFGRGTHSQLF
PQERLDFPIVGVATGSEHGILTTANQHCYNVYCWGWGEHGNCGPQKGSQP
GLQLVGQYSGKPRVFGGCATTWIVL
Ligand information
Ligand IDDXE
InChIInChI=1S/C4H10O2/c1-5-3-4-6-2/h3-4H2,1-2H3
InChIKeyXTHFKEDIFFGKHM-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O(C)CCOC
CACTVS 3.341
OpenEye OEToolkits 1.5.0		COCCOC
FormulaC4 H10 O2
Name1,2-DIMETHOXYETHANE
ChEMBLCHEMBL1232411
DrugBankDB01749
ZINCZINC000001690289
PDB chain4x33 Chain B Residue 406 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4x33 Structure of the Elongator cofactor complex Kti11/Kti13 provides insight into the role of Kti13 in Elongator-dependent tRNA modification.
Resolution1.45 Å
Binding residue
(original residue number in PDB)		R13 G18 H19 D20
Binding residue
(residue number reindexed from 1)		R12 G17 H18 D19
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0002098 tRNA wobble uridine modification
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008033 tRNA processing
GO:0016567 protein ubiquitination
GO:0017183 protein histidyl modification to diphthamide
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4x33, PDBe:4x33, PDBj:4x33
PDBsum4x33
PubMed25604895
UniProtP31386|ATS1_YEAST Protein KTI13 (Gene Name=ATS1)

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