Structure of PDB 4wvt Chain B Binding Site BS01
Receptor Information
>4wvt Chain B (length=79) Species:
9606
(Homo sapiens) [
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GHMRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFA
CGGKLKNWEPGDRAWSEHRRHFPNCFFVL
Ligand information
>4wvt Chain D (length=6) [
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AFPFFg
Receptor-Ligand Complex Structure
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PDB
4wvt
The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity.
Resolution
1.96 Å
Binding residue
(original residue number in PDB)
Q197 K206 L207 K208 W210 D214 E219 H223
Binding residue
(residue number reindexed from 1)
Q45 K54 L55 K56 W58 D62 E67 H71
Enzymatic activity
Enzyme Commision number
2.3.2.27
: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0043027
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Biological Process
GO:0043066
negative regulation of apoptotic process
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Molecular Function
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Biological Process
External links
PDB
RCSB:4wvt
,
PDBe:4wvt
,
PDBj:4wvt
PDBsum
4wvt
PubMed
25695766
UniProt
P98170
|XIAP_HUMAN E3 ubiquitin-protein ligase XIAP (Gene Name=XIAP)
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