Structure of PDB 4wlm Chain B Binding Site BS01

Receptor Information
>4wlm Chain B (length=290) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VDYHLLMMFTKAEHNAPLQAKARVALSSLLRLAKFEAHEVLNLHFVSEEA
SREVAKALLRELLFKCKVIFHDVAVLTDKLFPVVEAMQKYFSAGSGTYYS
DSIFFLSVAMHQIMPKEIPRIIQLDLDLKYKTNIRELFEEFDNFLPGAVI
GIAREMQPVYRHTFWQFRHENPKTRVGDPPPEGLPGFNSGVMLLNLEAMR
QSPLYSHLLEPSWVQQLADKYHFRGHLGDQDFFTMIGMEHPELFHVLDCT
WNRQLCTWWRDHGYSDVFQAYFRCEGHVKIYHGNCNTPIP
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain4wlm Chain B Residue 404 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4wlm Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		D225 D227 H382
Binding residue
(residue number reindexed from 1)		D125 D127 H282
Annotation score1
Enzymatic activity
Enzyme Commision number 2.4.2.62: xylosyl alpha-1,3-xylosyltransferase.
Gene Ontology
Molecular Function
GO:0016757 glycosyltransferase activity
GO:0035252 UDP-xylosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4wlm, PDBe:4wlm, PDBj:4wlm
PDBsum4wlm
PubMed26414444
UniProtQ3U4G3|XXLT1_MOUSE Xyloside xylosyltransferase 1 (Gene Name=Xxylt1)

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