Structure of PDB 4w8y Chain B Binding Site BS01

Receptor Information
>4w8y Chain B (length=828) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVNIKEKLFVYLHDPPDKALKIENHEERSKKILSSGNITDKVKQADALSS
KTQRFIIREPVIDFLGRSYFHVGYPVFIHPISTEIKRYETLEKYIDLGRS
NRGERFVNEFLERVSKLEGDVLKEVFEDASNKFKGEESKQWAYIWQFYPV
KLKEGVKEFAKSELKLKEEEAEKFAEEFVNLPADTRFPDHAIWTHLDLTS
ALSVKDPTLLRIKIVPVQPFIANSRKQLDLWASSHLLSMLMYKALEVIVD
KFGPEHVIYPSLRDQPFFLKFYLGENIGDEILVANLPNKALAIVSGKEAE
KIEEEIKKRIRDFLLQLYREAVDWAVENGVVKVDRSEKDSMLKEAYLKIV
REYFTVSITWVSLSEKEDIYQVTENAGLSDEDVKKWLKFAEKKENSRVLE
RIAIYPLLVKILDSLGERKVTEEEQLKGWKCHVCGENLAIFGDMYDHDNL
KSLWLDEEPLCPMCLIKRYYPVWIRSKTGQKIRFESVVDVALLYKNWRKI
FDEKYGKDLVSKAREVSEDFVKDNMLVDSDLYYSSTWESDEEKVKEVVDF
LNAAYKEIGNPPKYYAILVMDGDDMGKVISGEVLGEISTRIHPNIRDYVE
IPEAKYYSTPQVHVAISQALANFSIREVRSVVKDEGLLIYAGGDDVLAIL
PVDKALEVAYKIRKEFGKSFENGSLLPGWKLSAGILIVHYKHPLYDALEK
ARDLLNNKAKNVPGKDTLAIGLLKRSGSYYISLVGWELIRVFYNSELRKK
LLERFIYHVLREVDTWPIDEMLKFEVIRHIKEETKELREKIYGEIKDLLE
HVRGNNEVEKVRGLFTFLKIITDAEVFP
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4w8y Chain B Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4w8y Structural Model of a CRISPR RNA-Silencing Complex Reveals the RNA-Target Cleavage Activity in Cmr4.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		C448 C451 C478 C481
Binding residue
(residue number reindexed from 1)		C431 C434 C461 C464
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0051607 defense response to virus
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4w8y, PDBe:4w8y, PDBj:4w8y
PDBsum4w8y
PubMed25280103
UniProtQ8U1S6|CMR2_PYRFU CRISPR system Cmr subunit Cmr2 (Gene Name=cmr2)

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