Structure of PDB 4v0h Chain B Binding Site BS01

Receptor Information
>4v0h Chain B (length=221) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RTEPLCGASPLLVPGDPYSVVVLLQGYAEPEGVGDAVRADGSVTLVLPQG
AEAALEEAARGPILVDTGGPWAREALLGALAGQGVAPGDVTLVVGTHGHS
DHIGNLGLFPGAALLVSHDFCLPGGRYLPHGLGEGQPLRLGPGLEVWATP
GHGGQRDVSVVVAGTALGTVVVAGDVFERDGDEDSWQALSEDPAAQERSR
KRVLVVADVVVPGHGPPFRVL
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain4v0h Chain B Residue 1242 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4v0h Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease.
Resolution1.79 Å
Binding residue
(original residue number in PDB)		H117 H119 H122 H172 D195
Binding residue
(residue number reindexed from 1)		H97 H99 H102 H152 D175
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.27.-
Gene Ontology
Molecular Function
GO:0004521 RNA endonuclease activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0008334 histone mRNA metabolic process
GO:0031124 mRNA 3'-end processing
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4v0h, PDBe:4v0h, PDBj:4v0h
PDBsum4v0h
PubMed30507380
UniProtA4D2B0|MBLC1_HUMAN Metallo-beta-lactamase domain-containing protein 1 (Gene Name=MBLAC1)

[Back to BioLiP]